Bioassay/ Potency Scientist, Analytical Development CMC

Manufacturing · Harwell, Oxfordshire
Department Manufacturing
Employment Type Full-Time
Minimum Experience Experienced

The Company

 

Vaccitech plc is a fast-growing biotech company. At only six years old we already have a development portfolio of nine programmes, including a partnered product that is in commercial production and that has seen more than 3 billion doses administered worldwide and an IPO behind us. We are a publicly listed clinical stage biopharmaceutical company that spun out of the University of Oxford’s Jenner Institute, one of the most prestigious vaccine research centres in the world. We discover and develop immunotherapeutic products and vaccines for the treatment and prevention of infectious diseases, cancer, and autoimmunity. Our achievements include co-inventing and jointly developing our COVID-19 vaccine candidate VTP-900, now Vaxzevria, which we assigned to Oxford University Innovation to facilitate the licensing of those rights to AstraZeneca. We run clinical studies to explore treatments for patients with HBV and HPV infections and are developing rapid and scalable manufacturing processes for our platforms.

 

In December 2021, Vaccitech acquired Avidea Technologies Inc. with exciting product candidates for oncology and autoimmunity based on the innovative SNAPvax platform, which has demonstrated unprecedented control over T cell induction. This gives us U.S operational presence in Maryland, complements Vaccitech’s established capabilities and reinforces our position as a fast-growing global leader in immunotherapies and vaccines. Vaccitech's UK headquarters has recently moved to a state-of-the-art facility in the UK's leading science and innovation campus at Harwell. We conduct research globally and have ambitious plans in the UK and US, where we will continue to grow our teams over the coming months and years.

 

The role

 

As a member of the team, the Scientist is expected to perform multiple analytical techniques with a specific emphasise on cell-based potency assays (bioassays) that are required to support testing of Vaccitech’s products.

 

Work closely with team members within Vaccitech to assist with the development and qualification of lot release, stability and characterisation assays in accordance with Regulatory and Quality Guidelines.

 

Key responsibilities include, but are not limited to:

 

  • Develop, qualify and perform analytical techniques with a specific emphasis on development of cell-based potency (bio)assays that are required to support testing of Vaccitech’s products.
  • Work as part of a team specifically to develop, qualify and perform analytical assays for testing of drug product and drug substance and in-process samples to support Vaccitech CMC (Chemistry, Manufacturing and Control) activities.
  • Ensure all analytical development work is sufficiently documented to support regulatory submissions or intellectual property requirements when appropriate and all data collection and review activities are conducted in accordance with the company’s quality system and policies.
  • Supporting development of assays to analyse Vaccitech CMC (Chemistry, Manufacturing and Control) activities as required.
  • Contribute to the routine running of the laboratory and maintenance of the equipment
  • Write technical reports, standard operating procedures and other documents as required
  • Assist in the technical transfer of processes to relevant Contract Manufacturers as required
  • Participate in team and other scientific meetings, presenting data and conclusions as required
  • Adhere to applicable policies and procedures relating to working in the laboratory


Qualifications and experience required

 

  • A Ph.D or equivalent experience in a life science discipline.
  • One years practical laboratory experience, ideally gained in a Biotechnology/Pharmaceutical setting
  • Practical experience in cell-based potency assays and molecular techniques
  • Practical knowledge of mammalian cell culture.
  • Ability to write and record laboratory activities clearly and accurately.
  • Ability to analyze and research complex issues and write factual reports.
  • Knowledge and understanding of the following (or alternative technologies if relevant) such as ELISA, SDS-PAGE, Western Blot, cell-line generation and flow cytometry.
  • Understanding principles of Design of Experiments and relevant software


What we can offer you

 

Vaccitech is a great place to work. We encourage an entirely flat structure with an open-door policy to the senior leadership team. Our employees agree the culture and working environment is one of the best things about our business. As part of a small high growth business you will get the opportunity to be involved in many different areas and our rapid growth trajectory means you will have the opportunity to grow with us. We offer stock options to all employees, 25 days annual holidays increasing with length of service, an AXA Healthcare plan, Life Insurance and up to 5% pension contributions matched by the company.

 

Notice to recruiters

 

Vaccitech’s internal Talent Acquisition leads recruitment and employment for Vaccitech. Unsolicited resumes sent to Vaccitech from recruiters do not constitute any type of relationship between the recruiter and Vaccitech and do not obligate Vaccitech to pay fees should we hire from those resumes. Vaccitech operate a preferred list of recruitment suppliers, any and all equiries about joining us as a supplier should be directed to Vaccitech’s TA Team. We ask that external recruiters and/ or agencies not contact or present candidates directly to our hiring manager or employees.

 

Thank You

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  • Location
    Harwell, Oxfordshire
  • Department
    Manufacturing
  • Employment Type
    Full-Time
  • Minimum Experience
    Experienced